The Great Multitude Of Many Nations, as mentioned in Revelation 7:9-17, refers to the great "soul harvest" of people from all corners of the world who become believers through the preaching of the 144,000 sent out into all the world. This takes place from Soul Harvest until Glorious Appearing. Revelation 7:9 says that this is a great multitude that no one can count from every nation, land, tribe, and tongue. The authors may have interpreted Revelation 7:16 as indicating that God has conferred immunity from the blood plagues and heat of the Bowl Judgments to the Great Multitude.

In Busted!, Bruce Barnes prompted Lionel Washington to look up Revelation 9:16 in Bruce's copy of the King James Version. That verse cites the number of horsemen in the sixth Trumpet Judgment, which is "two-hundred thousand thousand". John, the author of Revelation, said that he "heard the number of them". Bruce Barnes reasons that this is a lower bound for the number of people who are a part of the Great Multitude, since the 200 million horseman can be counted (perhaps to six significant figures if "two-hundred thousand" was precise) but the number of people who are a part of the great multitude are expected to be qualitatively greater where they could not be counted. Bruce Barnes speculates that there may be a billion or more people who would come to Christ during the Tribulation.

In Apollyon, Tsion Ben-Judah stated that it thrills his heart that there are likely more Christ-followers during the Tribulation than were the number of people who had been raptured. He said that even nations with a minuscule number of Christians in the past now have many people coming into salvation.